(S)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

Base Information

Chemical Name:(S)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione
CAS No.:1447664-72-3
Molecular Formula:C₂₈H₃₀N₄O₂S
Molecular Weight:486.638
Hs Code.:

Synonyms:(S)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

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Chemical Property of (S)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

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Technology Process of (S)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

There total 8 articles about (S)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447664-71-2
rac-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

: 1447664-72-3
(S)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

: 1447664-73-4
(R)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

Guidance literature:: With Chiralpak AD-H column; In methanol; carbon dioxide; Resolution of racemate; liquid CO₂;

Reference yield:

: 1356332-75-6
2-bromo-3-chloro-7,8-dihydro-5H-pyrido[2,3-b]pyrazin-6-one

: 1447664-72-3
(S)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

: 1447664-73-4
(R)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 26 h / 110 °C / Inert atmosphere; Reflux

1.2: 1 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 18 h / 10 - 20 °C / Inert atmosphere

4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 16 h / 20 °C / Molecular sieve; Inert atmosphere

5.1: piperidine / ethanol / 3 h / Reflux

6.1: piperidine; lithium borohydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

7.1: Chiralpak AD-H column / methanol; carbon dioxide / Resolution of racemate; liquid CO₂

With piperidine; lithium borohydride; tetrapropylammonium perruthennate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; borane-THF; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; N,N-dimethyl-formamide;

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1447664-72-3
(S)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

: 1447664-73-4
(R)-5-(4-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)butyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 26 h / 110 °C / Inert atmosphere; Reflux

1.2: 1 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 18 h / 10 - 20 °C / Inert atmosphere

4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 16 h / 20 °C / Molecular sieve; Inert atmosphere

5.1: piperidine / ethanol / 3 h / Reflux

6.1: piperidine; lithium borohydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

7.1: Chiralpak AD-H column / methanol; carbon dioxide / Resolution of racemate; liquid CO₂

With piperidine; lithium borohydride; tetrapropylammonium perruthennate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; borane-THF; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; N,N-dimethyl-formamide;