methyl 2-methyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate

Base Information

Chemical Name:methyl 2-methyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate
CAS No.:287119-94-2
Molecular Formula:C₁₉H₂₀N₂O₆
Molecular Weight:372.378
Hs Code.:

Synonyms:methyl 2-methyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate

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Chemical Property of methyl 2-methyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate

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Technology Process of methyl 2-methyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate

There total 6 articles about methyl 2-methyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 287119-90-8
methyl 2-methyl-5-(N-methylamino)phenylacetate

: 4457-32-3
4-nitrobenzyl chloroformate

: 287119-94-2
methyl 2-methyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1039/b000135j

Reference yield:

: 644-36-0
o-methylphenylacetic acid

: 287119-94-2
methyl 2-methyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate

Guidance literature:: Multi-step reaction with 6 steps

1: HNO₃; conc. H₂SO₄ / -10 - 20 °C

2: 1.44 g / thionyl chloride / dimethylformamide / 16 h / 20 °C

3: H₂ / Pd/C / ethanol / 3102.97 Torr

4: tetrahydrofuran / -20 °C

5: BH₃*DMS / tetrahydrofuran / 20 °C

6: 92 percent / tetrahydrofuran / 20 °C

With thionyl chloride; dimethylsulfide borane complex; sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: Nitration / 2: Esterification / 3: Reduction / 4: Formylation / 5: Reduction / 6: Acylation;
DOI:10.1039/b000135j

Reference yield:

: 287119-84-0
2-methyl-5-nitrophenylacetic acid methyl ester

: 287119-94-2
methyl 2-methyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethanol / 3102.97 Torr

2: tetrahydrofuran / -20 °C

3: BH₃*DMS / tetrahydrofuran / 20 °C

4: 92 percent / tetrahydrofuran / 20 °C

With dimethylsulfide borane complex; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1: Reduction / 2: Formylation / 3: Reduction / 4: Acylation;
DOI:10.1039/b000135j