N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

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Chemical Name:N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide
CAS No.:1246761-03-4
Molecular Formula:C₂₀H₁₃F₅N₄O₃S₂
Molecular Weight:516.472
Hs Code.:

Synonyms:N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

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Chemical Property of N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

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Technology Process of N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

There total 20 articles about N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 957125-35-8
4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine

: ethyl (1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetate

: 1246761-03-4
N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

Guidance literature:: 4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine; With sodium hydride; In toluene; mineral oil; at 20 ℃;

ethyl (1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetate; In toluene; mineral oil; for 48h; Reflux;

Reference yield: 65.0%

: N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-4-[(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)thio]-3-oxobutanamide

: 1246761-03-4
N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

Guidance literature:: With phosphorus pentoxide; In toluene; for 2h; Reflux;

Reference yield: 15.0%

: 957125-35-8
4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine

: 5-[2-(1H-benzotriazol-1-yl)-2-oxoethyl]-1,3-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)dione

: 1246761-03-4
N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

Guidance literature:: 4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

5-[2-(1H-benzotriazol-1-yl)-2-oxoethyl]-1,3-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)dione; In toluene; mineral oil; for 24h; Reflux;