Carbamic acid, [(1S)-2-hydroxy-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl

Base Information

• Chemical Name: Carbamic acid, [(1S)-2-hydroxy-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl
• CAS No.: 721927-59-9
• Molecular Formula: C₉H₁₉NO₄
• Molecular Weight: 205.254
• Hs Code.: 2924297099
• Mol file: 721927-59-9.mol

Synonyms:Carbamicacid, [(1S)-2-hydroxy-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, [(1S)-2-hydroxy-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-D-Ser(Me)-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(1S)-2-hydroxy-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl

There total 18 articles about Carbamic acid, [(1S)-2-hydroxy-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

((S)-2-Benzyloxy-1-methoxymethyl-ethyl)-carbamic acid tert-butyl ester (183793-48-8) → (R)-tert-butyl 1-hydroxy-3-methoxy propan-2-yl carbamate (183793-49-9,721927-59-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 24h;

DOI:10.1021/jo961408a

Reference yield: 86.0%

tert-butyl (R)-4-(methoxymethyl)-2,2-dimethyloxazolidine-3-carboxylate (721928-19-4) → tert-butyl [(2R)-1-hydroxy-3-methoxypropan-2-yl]carbamate (721927-59-9)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In methanol; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2015.08.077

Reference yield: 86.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-((2-azido-3-methoxypropoxy)methyl)benzene (1334286-16-6) → tert-butyl [(2R)-1-hydroxy-3-methoxypropan-2-yl]carbamate (721927-59-9)

Guidance literature:

With 20 % Pd(OH)2/C; hydrogen; In ethyl acetate; for 36h; under 3102.97 Torr;

DOI:10.1016/j.tetasy.2011.07.024

upstream raw materials:

tert-butyl (R)-4-(methoxymethyl)-2,2-dimethyloxazolidine-3-carboxylate

4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate

(R)-((2-azido-3-methoxypropoxy)methyl)benzene