2-(2-benzyloxycarbonylamino-ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6,7-dicarboxylic acid

Base Information

• Chemical Name: 2-(2-benzyloxycarbonylamino-ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6,7-dicarboxylic acid
• CAS No.: 849543-70-0
• Molecular Formula: C₂₄H₁₈N₂O₈
• Molecular Weight: 462.416
• Mol file: 849543-70-0.mol

Synonyms:2-(2-benzyloxycarbonylamino-ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6,7-dicarboxylic acid

Chemical Property of 2-(2-benzyloxycarbonylamino-ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6,7-dicarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-benzyloxycarbonylamino-ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6,7-dicarboxylic acid

There total 2 articles about 2-(2-benzyloxycarbonylamino-ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6,7-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-benzyloxycarbonylaminoethylamine (72080-83-2) + 1,4,5,8-naphthalenetetracarboxylic dianhydride (81-30-1) → 2-(2-benzyloxycarbonylamino-ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6,7-dicarboxylic acid (849543-70-0)

Guidance literature:

1,4,5,8-naphthalenetetracarboxylic dianhydride; With potassium hydroxide; In water; at 20 ℃; pH=6.4;

2-benzyloxycarbonylaminoethylamine; In water; pH=6.4; Further stages.; Heating;

DOI:10.1021/ja0665747

Reference yield:

monoanhydride of 1,4,5,8-naphthalenetetracarboxylic acid (52671-72-4) + benzyl N-(2-aminoethyl)carbamate hydrochloride (18807-71-1) → 2-(2-benzyloxycarbonylamino-ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6,7-dicarboxylic acid (849543-70-0)

Guidance literature:

With phosphoric acid; at 110 ℃; pH=6.4;

DOI:10.1002/chem.200400923

Reference yield: 57.0%

2-(2-benzyloxycarbonylamino-ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6,7-dicarboxylic acid (849543-70-0) + N,N'-bis(4-amino-2,3,5,6-tetramethylphenyl)naphthalene-1,4,5,8-dicarboxyimide → C82H60N8O16

Guidance literature:

In N,N-dimethyl acetamide; at 135 ℃; for 12h;

DOI:10.1021/ja0665747

upstream raw materials:

monoanhydride of 1,4,5,8-naphthalenetetracarboxylic acid

benzyl N-(2-aminoethyl)carbamate hydrochloride

2-benzyloxycarbonylaminoethylamine

1,4,5,8-naphthalenetetracarboxylic dianhydride