(S)-2-acetamido-N₁-((R)-1-((2R,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide

Base Information

• Chemical Name: (S)-2-acetamido-N₁-((R)-1-((2R,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide
• CAS No.: 906537-67-5
• Molecular Formula: C₃₄H₄₃N₅O₅
• Molecular Weight: 601.746

Synonyms:(S)-2-acetamido-N₁-((R)-1-((2R,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide

Chemical Property of (S)-2-acetamido-N₁-((R)-1-((2R,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide

Chemical Property:

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Technology Process of (S)-2-acetamido-N₁-((R)-1-((2R,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide

There total 8 articles about (S)-2-acetamido-N₁-((R)-1-((2R,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-acetamido-N1-((R)-1-((2R,4S)-2-(3-azidopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide (906537-66-4) → (S)-2-acetamido-N1-((R)-1-((2R,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide (906537-67-5)

Guidance literature:

With pyridine; hydrogen; palladium on activated charcoal; In methanol; for 5h;

DOI:10.1021/jm060384p

Reference yield:

(2R,4S)-2-(3-azidopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine (906537-10-8) → (S)-2-acetamido-N1-((R)-1-((2R,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide (906537-67-5)

Guidance literature:

Multi-step reaction with 4 steps

1: HOAt; 4-methylmorpholine; ethyldimethylaminopropyl carbodiimide / dimethylformamide / 1.25 h

2: aq. TFA / CH₂Cl₂ / 1 h

3: 38 percent / 1H-benzotriazole; 4-methylmorpholine; ethyldimethylaminopropyl carbodiimide / dimethylformamide / 1 h

4: H₂; pyridine / Pd/C / methanol / 5 h

With 4-methyl-morpholine; pyridine; 1,2,3-Benzotriazole; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm060384p

Reference yield:

tert-butyl (4S)-2-allyl-4-(naphthalen-2-ylmethoxy)pyrrolidine-1-carboxylate → (S)-2-acetamido-N1-((R)-1-((2R,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide (906537-67-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: BH₃-THF / tetrahydrofuran / 0.5 h

1.2: 1.0 g / aq. NaOH; H₂O₂ / tetrahydrofuran / 2 h

2.1: Et₃N / CH₂Cl₂ / 0.75 h / 20 °C

3.1: NaN₃ / dimethylsulfoxide / 3 h / 70 °C

4.1: aq. TFA / CH₂Cl₂ / 1 h

5.1: HOAt; 4-methylmorpholine; ethyldimethylaminopropyl carbodiimide / dimethylformamide / 1.25 h

6.1: aq. TFA / CH₂Cl₂ / 1 h

7.1: 38 percent / 1H-benzotriazole; 4-methylmorpholine; ethyldimethylaminopropyl carbodiimide / dimethylformamide / 1 h

8.1: H₂; pyridine / Pd/C / methanol / 5 h

With 4-methyl-morpholine; pyridine; 1,2,3-Benzotriazole; sodium azide; 1-hydroxy-7-aza-benzotriazole; borane-THF; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm060384p

upstream raw materials:

(S)-2-acetamido-N₁-((R)-1-((2R,4S)-2-(3-azidopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)pentanediamide

(2R,4S)-2-(3-azidopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine

tert-butyl (2R,4S)-2-(3-hydroxypropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-1-carboxylate

tert-butyl (2R,4S)-2-(3-azidopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-1-carboxylate

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