{1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester
CAS No.:367258-50-2
Molecular Formula:C₂₄H₃₈N₄O₆
Molecular Weight:478.589
Hs Code.:

{1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester

Suppliers and Price of {1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester

There total 18 articles about {1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 367258-50-2
{1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 4.86 g / HATU; DIPEA / CH₂Cl₂ / 18 h / -20 °C

2: 99 percent / HCl / dioxane / 4 h / 20 °C

3: HATU; DIPEA / CH₂Cl₂ / 18 h / -20 °C

4: 2.1 g / HCl / dioxane

5: HATU; DIPEA / CH₂Cl₂ / 18 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm060077j

Reference yield:

: (3-tert-butoxycarbonylamino-2-hydroxy-heptanoylamino)-acetic acid benzyl ester

: 367258-50-2
{1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on carbon / ethanol / 20 °C

2: 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; EDC; N-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 °C

With 4-methyl-morpholine; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200501553

Reference yield:

: 254438-03-4
(2RS,3S)-2-hydroxy-3-[N-(2-methyl-2-propyloxycarbonyl)amino]heptanoic acid

: 367258-50-2
{1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; EDC; N-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 °C

2: hydrogen / palladium on carbon / ethanol / 20 °C

3: 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; EDC; N-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 °C

With 4-methyl-morpholine; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200501553