[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid

Base Information

Chemical Name:[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid
CAS No.:1392841-33-6
Molecular Formula:C₁₈H₁₅N₃O₅
Molecular Weight:353.334
Hs Code.:

Synonyms:[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid

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Chemical Property of [(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid

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Technology Process of [(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid

There total 4 articles about [(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392838-92-4
1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylic acid methyl ester

: 6000-44-8
sodium glycinate

: 1392841-33-6
[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid

Guidance literature:: 1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylic acid methyl ester; sodium glycinate; In 2-methoxy-ethanol; for 2h; Reflux;

With sodium hydrogencarbonate;

With hydrogenchloride; In water;

Reference yield:

: 100-46-9
benzylamine

: 1392841-33-6
[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 2 h / Reflux

1.2: 48 h / Reflux

2.1: triethylamine / methanol / 23 h / Reflux

2.2: 16 h / Reflux

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium methylate / methanol / 16 h

6.1: 2-methoxy-ethanol / 2 h / Reflux

With N-Bromosuccinimide; sodium methylate; potassium carbonate; triethylamine; sodium iodide; dibenzoyl peroxide; In methanol; tetrachloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1392838-84-4
1-benzyl-2-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

: 1392841-33-6
[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

3: sodium methylate / methanol / 16 h

4: 2-methoxy-ethanol / 2 h / Reflux

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; In methanol; tetrachloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide;