Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester

Base Information

• Chemical Name: Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester
• CAS No.: 169613-97-2
• Molecular Formula: C₂₂H₃₃NO₅
• Molecular Weight: 391.508
• Mol file: 169613-97-2.mol

Synonyms:Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester

Chemical Property of Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester

There total 4 articles about Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

1-(N-acetyl-N-isopropyl)amino-3-<4-(2-cyclopropylmethoxy)ethyl>phenoxyprop-2-yl acetate (169613-96-1) → Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester (169613-97-2)

Guidance literature:

With Rhodotorula mucilaginosa DQ₈₃₂₁₉₈; at 28 ℃; for 12h; pH=6; enantioselective reaction; Microbiological reaction; phosphate-citric acid buffer;

DOI:10.1080/00397911.2010.505699

Reference yield:

betaxolol (63659-18-7) + acetic anhydride (108-24-7) → N-{(R)-3-[4-(2-Cyclopropylmethoxy-ethyl)-phenoxy]-2-hydroxy-propyl}-N-isopropyl-acetamide + Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester (169613-97-2)

Guidance literature:

With pyridine; for 24h; Yield given. Yields of byproduct given; Ambient temperature;

Reference yield:

betaxolol (63659-18-7) → Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester (169613-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; triethylamine / 20 °C

2: Rhodotorula mucilaginosa DQ₈₃₂₁₉₈ / 12 h / 28 °C / pH 6 / Microbiological reaction; phosphate-citric acid buffer

With pyridine; triethylamine;

DOI:10.1080/00397911.2010.505699

upstream raw materials:

betaxolol

acetic anhydride

1-(N-acetyl-N-isopropyl)amino-3-<4-(2-cyclopropylmethoxy)ethyl>phenoxyprop-2-yl acetate

Downstream raw materials:

(+)-Betaxolol

(-)-Betaxolol