tert-butyl 4-[[4-(2-ethylbutanoyl)phenyl](phenyl)methyl]-1-piperazinecarboxylate

Base Information

Chemical Name:tert-butyl 4-[[4-(2-ethylbutanoyl)phenyl](phenyl)methyl]-1-piperazinecarboxylate
CAS No.:308110-12-5
Molecular Formula:C₂₈H₃₈N₂O₃
Molecular Weight:450.621
Hs Code.:

Synonyms:tert-butyl 4-[[4-(2-ethylbutanoyl)phenyl](phenyl)methyl]-1-piperazinecarboxylate

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Chemical Property of tert-butyl 4-[[4-(2-ethylbutanoyl)phenyl](phenyl)methyl]-1-piperazinecarboxylate

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Technology Process of tert-butyl 4-[[4-(2-ethylbutanoyl)phenyl](phenyl)methyl]-1-piperazinecarboxylate

There total 3 articles about tert-butyl 4-[[4-(2-ethylbutanoyl)phenyl](phenyl)methyl]-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 2-ethyl-N-methoxy-N-methylbutanamide

: 308110-11-4
tert-butyl 4-[(4-bromophenyl)(phenyl)methyl]-1-piperazinecarboxylate

: 308110-12-5
tert-butyl 4-[[4-(2-ethylbutanoyl)phenyl](phenyl)methyl]-1-piperazinecarboxylate

Guidance literature:: tert-butyl 4-[(4-bromophenyl)(phenyl)methyl]-1-piperazinecarboxylate; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃;

2-ethyl-N-methoxy-N-methylbutanamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jm000228x

Reference yield:

: 29334-16-5
phenyl(4-bromophenyl)methanol

: 308110-12-5
tert-butyl 4-[[4-(2-ethylbutanoyl)phenyl](phenyl)methyl]-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / SOCl₂ / CH₂Cl₂ / 1 h / 25 °C

2.1: 81 percent / diisopropylethylamine; KI / acetonitrile / 80 °C

3.1: t-BuLi / tetrahydrofuran; hexane / -78 °C

3.2: 25 percent / tetrahydrofuran; hexane / -78 - 20 °C

With thionyl chloride; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 1.1: Chlorination / 2.1: Substitution / 3.1: Metallation / 3.2: Addition;
DOI:10.1021/jm000228x

Reference yield:

: 13391-38-3
4-bromo-benzhydryl chloride

: 308110-12-5
tert-butyl 4-[[4-(2-ethylbutanoyl)phenyl](phenyl)methyl]-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / diisopropylethylamine; KI / acetonitrile / 80 °C

2.1: t-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 25 percent / tetrahydrofuran; hexane / -78 - 20 °C

With tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; hexane; acetonitrile; 1.1: Substitution / 2.1: Metallation / 2.2: Addition;
DOI:10.1021/jm000228x