2-(2-fluorophenyl)-3-methoxyacrylonitrile

Base Information

• Chemical Name: 2-(2-fluorophenyl)-3-methoxyacrylonitrile
• CAS No.: 442-21-7
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177.178
• Mol file: 442-21-7.mol

Synonyms:2-(2-fluorophenyl)-3-methoxyacrylonitrile

Chemical Property of 2-(2-fluorophenyl)-3-methoxyacrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-fluorophenyl)-3-methoxyacrylonitrile

There total 4 articles about 2-(2-fluorophenyl)-3-methoxyacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-(2-fluorophenyl)-3-hydroxyacrylonitrile (154858-21-6) + dimethyl sulfate (77-78-1) → 2-(2-fluorophenyl)-3-methoxyacrylonitrile (442-21-7)

Guidance literature:

2-(2-fluorophenyl)-3-hydroxyacrylonitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

dimethyl sulfate; In tetrahydrofuran; at 40 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.08.027

Reference yield:

2-fluorophenyl acetonitrile (326-62-5) → 2-(2-fluoro-phenyl)-3-methoxy-acrylonitrile (442-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethylate

With sodium ethanolate;

DOI:10.1021/ja01152a060

Reference yield:

2-fluorophenyl acetonitrile (326-62-5) → 2-(2-fluorophenyl)-3-methoxyacrylonitrile (442-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 40 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2014.08.027

upstream raw materials:

diazomethane

2-(2'-Fluorophenyl)-3-oxopropanenitrile

2-fluorophenyl acetonitrile

2-(2-fluorophenyl)-3-hydroxyacrylonitrile

Downstream raw materials:

7-(2-fluorophenyl)-3-(4-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

methyl 3-amino-4-(2-fluorophenyl)thiophene-2-carboxylate

3-cycloheptyl-7-(2-fluorophenyl)thieno[3,2-d]pyrimidin-4(3H)-one

3-cyclooctyl-7-(2-fluorophenyl)thieno[3,2-d]pyrimidin-4(3H)-one