6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-hexansaeure-Ethylester

Base Information

Chemical Name:6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-hexansaeure-Ethylester
CAS No.:157977-18-9
Molecular Formula:C₃₀H₃₂ClNO₆S
Molecular Weight:570.106
Hs Code.:

Synonyms:6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-hexansaeure-Ethylester

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Chemical Property of 6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-hexansaeure-Ethylester

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Technology Process of 6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-hexansaeure-Ethylester

There total 7 articles about 6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-hexansaeure-Ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 157977-17-8
6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-6-hydroxyhexansaeure-Ethylester

: 157977-18-9
6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-hexansaeure-Ethylester

Guidance literature:: With trifluoroacetic acid; HSiPh₃; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1002/ardp.19943270602

Reference yield:

: 1071-71-2
ethyl 6-chloro-6-oxohexanoate

: 157977-18-9
6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-hexansaeure-Ethylester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / AlCl₃ / CH₂Cl₂ / 1 h

2: 84 percent / NaBH₄ / methanol / 0 deg C to r.t.

3: 84 percent / 1.) (C₆H₅)3SiH, CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

With sodium tetrahydroborate; aluminium trichloride; trifluoroacetic acid; HSiPh₃; In methanol; dichloromethane;
DOI:10.1002/ardp.19943270602

Reference yield:

: 62655-56-5
2-(4'-methoxy-phenyl)-6-methoxy-indole

: 157977-18-9
6-<3-Chlor-6-methoxy-2-(4-methoxyphenyl)-1-phenylsulfonyl-indol-5-yl>-hexansaeure-Ethylester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1.6M n-BuLi / 1.) THF, C₆H₁₄, -78 deg C, 3 h, 2.) THF, C₆H₁₄, -78 deg C to r.t., overnight

2: 55 percent / AlCl₃ / CH₂Cl₂ / 1 h

3: 84 percent / NaBH₄ / methanol / 0 deg C to r.t.

4: 84 percent / 1.) (C₆H₅)3SiH, CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

With sodium tetrahydroborate; n-butyllithium; aluminium trichloride; trifluoroacetic acid; HSiPh₃; In methanol; dichloromethane;
DOI:10.1002/ardp.19943270602