(+/-)-(1aR^*,8R^*,8aR^*,8bS^*)-7-benzyloxy-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-5-methylazirino<2',3':3,4>pyrrolo<1,2-a>indole

Base Information

• Chemical Name: (+/-)-(1aR^*,8R^*,8aR^*,8bS^*)-7-benzyloxy-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-5-methylazirino<2',3':3,4>pyrrolo<1,2-a>indole
• CAS No.: 96502-83-9
• Molecular Formula: C₂₉H₃₂N₂O₄
• Molecular Weight: 472.584

Synonyms:(+/-)-(1aR^*,8R^*,8aR^*,8bS^*)-7-benzyloxy-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-5-methylazirino<2',3':3,4>pyrrolo<1,2-a>indole

Chemical Property of (+/-)-(1aR^*,8R^*,8aR^*,8bS^*)-7-benzyloxy-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-5-methylazirino<2',3':3,4>pyrrolo<1,2-a>indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(1aR^*,8R^*,8aR^*,8bS^*)-7-benzyloxy-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-5-methylazirino<2',3':3,4>pyrrolo<1,2-a>indole

There total 7 articles about (+/-)-(1aR^*,8R^*,8aR^*,8bS^*)-7-benzyloxy-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-5-methylazirino<2',3':3,4>pyrrolo<1,2-a>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H37N2O7P (96502-82-8) → (+/-)-(1aR*,8R*,8aR*,8bS*)-7-benzyloxy-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-5-methylazirino<2',3':3,4>pyrrolo<1,2-a>indole (96502-83-9)

Guidance literature:

With lithium aluminium tetrahydride; at 0 ℃; for 0.75h; Yield given;

DOI:10.1021/ja00299a022

Reference yield:

Methanesulfonic acid (1R,2R,9S,9aS)-8-benzyloxy-9-benzyloxymethyl-2-(dimethoxy-phosphorylamino)-5,7-dimethoxy-6-methyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl ester (96502-81-7) → (+/-)-(1aR*,8R*,8aR*,8bS*)-7-benzyloxy-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-5-methylazirino<2',3':3,4>pyrrolo<1,2-a>indole (96502-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent NaH / paraffin; tetrahydrofuran / 4 h / Ambient temperature

2: 1 M LiAlH₄ / 0.75 h / 0 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; paraffin;

DOI:10.1021/ja00299a022

Reference yield:

Methanesulfonic acid (1R,2S,9S,9aS)-8-benzyloxy-9-benzyloxymethyl-1-hydroxy-5,7-dimethoxy-6-methyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indol-2-yl ester (96502-78-2) → (+/-)-(1aR*,8R*,8aR*,8bS*)-7-benzyloxy-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-5-methylazirino<2',3':3,4>pyrrolo<1,2-a>indole (96502-83-9)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrabutylammonium azide / benzene / 2.5 h / Heating

2: triethylamine / CH₂Cl₂ / 2 h / 0 °C

3: tetrahydrofuran / 4 h / Heating

4: 60 percent NaH / paraffin; tetrahydrofuran / 4 h / Ambient temperature

5: 1 M LiAlH₄ / 0.75 h / 0 °C

With lithium aluminium tetrahydride; tetrabutylammoniun azide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; paraffin; benzene;

DOI:10.1021/ja00299a022

upstream raw materials:

C₃₁H₃₇N₂O₇P

(+/-)-(1S^*,2R^*,9R^*,9aR^*)-8-benzyloxy-9-<(benzyloxy)methyl>-2,3,9,9a-tetrahydro-5,7-dimethoxy-6-methyl-1H-pyrrolo<1,2-a>indole-1,2-diol

Methanesulfonic acid (1R,2S,9S,9aS)-8-benzyloxy-9-benzyloxymethyl-1-hydroxy-5,7-dimethoxy-6-methyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indol-2-yl ester

Methanesulfonic acid (1R,2R,9S,9aS)-8-benzyloxy-9-benzyloxymethyl-2-(dimethoxy-phosphorylamino)-5,7-dimethoxy-6-methyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl ester

Downstream raw materials:

C₂₂H₂₆N₂O₄

(+/-)-(1aR^*,8R^*,8aR^*,8bS^*)-7-(benzyloxy)-8-<(benzyloxy)methyl>-1,1a,2,8,8a,8b-hexahydro-4,6-dimethoxy-1,5-dimethylazirino<2',3':3,4>pyrrolo<1,2-a>indole

C₂₃H₂₈N₂O₅

C₃₀H₃₄N₂O₅

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