Technology Process of 2-(4-(trifluoromethyl)pyridin-2-yl)-5,8-dioxaspiro[3.4]octane-2-carbonitrile
There total 2 articles about 2-(4-(trifluoromethyl)pyridin-2-yl)-5,8-dioxaspiro[3.4]octane-2-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C / Reflux
2: potassium hexamethylsilazane / toluene / 4 h / 60 °C
With
potassium hexamethylsilazane; toluene-4-sulfonic acid;
In
toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ruthenium(III) trichloride hydrate; sodium periodate / water; dichloromethane; acetonitrile / 0.17 h / 5 - 20 °C
2: toluene-4-sulfonic acid / toluene / 2 h / 20 °C / Reflux
3: potassium hexamethylsilazane / toluene / 4 h / 60 °C
With
sodium periodate; ruthenium(III) trichloride hydrate; potassium hexamethylsilazane; toluene-4-sulfonic acid;
In
dichloromethane; water; toluene; acetonitrile;
