(2R,3R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-butyraldehyde

Base Information

Chemical Name:(2R,3R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-butyraldehyde
CAS No.:221007-82-5
Molecular Formula:C₁₇H₂₄O₄
Molecular Weight:292.375
Hs Code.:

Synonyms:(2R,3R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-butyraldehyde

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Chemical Property of (2R,3R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-butyraldehyde

Chemical Property:

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Technology Process of (2R,3R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-butyraldehyde

There total 4 articles about (2R,3R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221007-81-4
(S)-4-<(2R,3S)-2-(benzyloxy)-3-methylpent-4-enyl>-2,2-dimethyl(1,3)dioxolane

: 221007-82-5
(2R,3R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-butyraldehyde

Guidance literature:: With sudan red; ozone; triphenylphosphine; In dichloromethane; at -78 - 22 ℃;
DOI:10.1021/jo981310r

Reference yield:

: 32233-43-5
2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

: 221007-82-5
(2R,3R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-butyraldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -78 °C

2: 4 Angstroem molecular sieves / toluene / -78 °C

3: 83 percent / NaH, Bu₄NI / tetrahydrofuran; dimethylformamide / 3 h / 23 °C

4: 1.) O₃, Sudan Red, 2.) Ph₃P / CH₂Cl₂ / -78 - 22 °C

With oxalyl dichloride; 4 A molecular sieve; sudan red; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo981310r

Reference yield:

: 32233-44-6
2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde

: 221007-82-5
(2R,3R)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-butyraldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 4 Angstroem molecular sieves / toluene / -78 °C

2: 83 percent / NaH, Bu₄NI / tetrahydrofuran; dimethylformamide / 3 h / 23 °C

3: 1.) O₃, Sudan Red, 2.) Ph₃P / CH₂Cl₂ / -78 - 22 °C

With 4 A molecular sieve; sudan red; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo981310r