N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester

Base Information

Chemical Name:N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester
CAS No.:1163765-11-4
Molecular Formula:C₁₆H₁₆FN₃O₃S
Molecular Weight:349.386
Hs Code.:

Synonyms:N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester

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Chemical Property of N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester

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Technology Process of N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester

There total 1 articles about N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1163765-10-3
N-(2-fluoro-4-methylsulfanyl-phenyl)-malonamic acid methyl ester

: 54198-81-1
4-pyrimidinylmethyl chloride

: 1163765-11-4
N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester

Guidance literature:: With potassium hydroxide; In isopropyl methanesulfonate; at 20 ℃; for 16h;

Reference yield: 42.0%

: 1163765-11-4
N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester

: 1163765-13-6
7-(2-fluoro-4-methylsulfanyl-phenylamino)-pyrrolo[1,2-c]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:: N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester; With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; for 1h; Heating / reflux;

With water; sodium hydrogencarbonate; Saturated solution;