dimethyl 2-(2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl)malonate

Base Information

• Chemical Name: dimethyl 2-(2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl)malonate
• CAS No.: 1432791-44-0
• Molecular Formula: C₂₃H₂₅NO₅
• Molecular Weight: 395.455
• Mol file: 1432791-44-0.mol

Synonyms:dimethyl 2-(2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl)malonate

Chemical Property of dimethyl 2-(2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl)malonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of dimethyl 2-(2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl)malonate

There total 1 articles about dimethyl 2-(2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-methylindole (603-76-9) + dimethyl 2-(4-methoxyphenyl)cyclopropane-1,1-dicarboxylate (75073-97-1) → dimethyl 2-(2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl)malonate (1432791-44-0)

Guidance literature:

With ytterbium(III) triflate; In 1,2-dichloro-ethane; at 20 - 65 ℃; Catalytic behavior; Inert atmosphere;

DOI:10.1016/j.tet.2015.12.001

Reference yield: 89.0%

dimethyl 2-(2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl)malonate (1432791-44-0) → 2-[2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl]malonic acid

Guidance literature:

dimethyl 2-(2-(4-methoxyphenyl)-2-(1-methyl-1H-indol-3-yl)ethyl)malonate; With water; sodium hydroxide; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In methanol; water;

DOI:10.1016/j.tet.2015.12.001

upstream raw materials:

1-methylindole

dimethyl 2-(4-methoxyphenyl)cyclopropane-1,1-dicarboxylate