Technology Process of 3-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoic acid lithium salt
There total 10 articles about 3-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoic acid lithium salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
at 80 ℃;
for 2.08333h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 15 h / 65 °C
2: triethylamine / N,N-dimethyl-formamide / 0 - 120 °C / Inert atmosphere
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C
4: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere
5: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.58 h / 20 - 100 °C / Inert atmosphere; In a sealed tube; Microwave irradiation
6: water; lithium hydroxide / tetrahydrofuran; methanol / 2.08 h / 80 °C
With
hydroxylamine hydrochloride; water; sodium hydrogencarbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; trichlorophosphate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / N,N-dimethyl-formamide / 0 - 120 °C / Inert atmosphere
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C
3: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere
4: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.58 h / 20 - 100 °C / Inert atmosphere; In a sealed tube; Microwave irradiation
5: water; lithium hydroxide / tetrahydrofuran; methanol / 2.08 h / 80 °C
With
water; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; trichlorophosphate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;
