4-[(2-AMino-acetylaMino)-Methyl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[(2-AMino-acetylaMino)-Methyl]-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 226249-72-5
• Molecular Formula: C₁₃H₂₅N₃O₃
• Molecular Weight: 271.36
• Mol file: 226249-72-5.mol

Synonyms:4-{(glycylamino)methyl}-1-(tert-butoxycarbonyl)piperidine

Chemical Property of 4-[(2-AMino-acetylaMino)-Methyl]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

tert-Butyl4-((2-aminoacetamido)methyl)piperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2-AMino-acetylaMino)-Methyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-[(2-AMino-acetylaMino)-Methyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-[{(N-(benzyloxycarbonyl)glycyl)amino}methyl]-1-(tert-butoxycarbonyl)piperidine (226249-70-3) → 4-{(glycylamino)methyl}-1-(tert-butoxycarbonyl)piperidine (226249-72-5)

Guidance literature:

In methanol; palladium on charcoal;

Reference yield:

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride (359629-16-6) → 4-{(glycylamino)methyl}-1-(tert-butoxycarbonyl)piperidine (226249-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / HOBt; EDC; Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: H₂ / Pd/C / methanol / 3 h / 20 °C / atmospheric pressure

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm050234z

Reference yield: 78.0%

4-{(glycylamino)methyl}-1-(tert-butoxycarbonyl)piperidine (226249-72-5) + 5-chloroanthranilic acid (635-21-2) → 4-[{(N-(2-amino-5-chlorobenzoyl)glycyl)amino}methyl]-1-(tert-butoxycarbonyl)piperidine

Guidance literature:

With sodium hydroxide; benzotriazol-1-ol; triethylamine; In chloroform;

upstream raw materials:

4-[{(N-(benzyloxycarbonyl)glycyl)amino}methyl]-1-(tert-butoxycarbonyl)piperidine

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride

Downstream raw materials:

4-{[({bis[10-({1-[2-(4-amino-5-chloro-2-methoxybenzoyloxy)ethyl]piperidin-4-yl}carbamoyl)decyl]amino}acetyl)amino]methyl}piperidine-1-carboxylic acid tert-butyl ester

4-[(2-{4-[2-(2,4-dichloro-phenoxy)-phenylsulfamoyl]-benzoylamino}-acetylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

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