4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride

Base Information

• Chemical Name: 4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride
• CAS No.: 1246633-23-7
• Molecular Formula: C₁₂H₁₅F₂NO*ClH
• Molecular Weight: 263.715

Synonyms:4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride

Chemical Property of 4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride

Chemical Property:

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Technology Process of 4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride

There total 1 articles about 4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4- [(2,4-difluorophenyl)methyl]-4-hydroxypiperidine-1-carboxylate (1429505-85-0) → 4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride (1246633-23-7)

Guidance literature:

With hydrogenchloride; ethanol; at 10 - 35 ℃;

Reference yield:

[2,4’-bipyridine]-3-carboxylic acid dihydrochloride + 4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride (1246633-23-7) → 2,4'-bipyridin-3-yl(4-(2,4-difluorobenzyl)-4-hydroxypiperidin-1-yl)methanone (1429505-46-3)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 18h;

Reference yield:

2-(pyrimidin-4-yl)nicotinic acid dihydrochloride + 4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride (1246633-23-7) → (4-(2,4-difluorobenzyl)-4-hydroxypiperidin-1-yl)(2-(pyrimidin-4-yl)pyridin-3-yl)methanone (1429505-67-8)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 10 - 35 ℃;

upstream raw materials:

tert-butyl 4- [(2,4-difluorophenyl)methyl]-4-hydroxypiperidine-1-carboxylate

Downstream raw materials:

2,4'-bipyridin-3-yl(4-(2,4-difluorobenzyl)-4-hydroxypiperidin-1-yl)methanone

(4-(2,4-difluorobenzyl)-4-hydroxypiperidin-1-yl)(2-(pyrimidin-4-yl)pyridin-3-yl)methanone

(4-(2,4-difluorobenzyl)-4-hydroxypiperidin-1-yl)(2-(1,3-oxazol-5-yl)phenyl)methanone

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