N-{3-[6-(2-amino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-yl}cyclohexane-1,4-diamine hydrochloride

Base Information

Chemical Name:N-{3-[6-(2-amino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-yl}cyclohexane-1,4-diamine hydrochloride
CAS No.:1400670-08-7
Molecular Formula:C₂₅H₃₀N₈*ClH
Molecular Weight:479.028
Hs Code.:

Synonyms:N-{3-[6-(2-amino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-yl}cyclohexane-1,4-diamine hydrochloride

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Chemical Property of N-{3-[6-(2-amino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-yl}cyclohexane-1,4-diamine hydrochloride

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Technology Process of N-{3-[6-(2-amino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-yl}cyclohexane-1,4-diamine hydrochloride

There total 10 articles about N-{3-[6-(2-amino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-yl}cyclohexane-1,4-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400670-55-4
(4-{3-[6-(2-tert-butoxycarbonylamino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-ylamino}cyclohexyl)carbamic acid tert-butyl ester

: 1400670-08-7
N-{3-[6-(2-amino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-yl}cyclohexane-1,4-diamine hydrochloride

Guidance literature:: In ethanol;

Reference yield:

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 1400670-08-7
N-{3-[6-(2-amino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-yl}cyclohexane-1,4-diamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -10 °C

1.2: 12 h / 20 °C

2.1: N-Bromosuccinimide / 0.5 h / 0 °C

3.1: toluene-4-sulfonic acid / acetonitrile; water / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 140 °C

5.1: potassium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 17 h / 135 °C / sealed tube; Inert atmosphere

6.1: ethanol

With N-Bromosuccinimide; potassium carbonate; toluene-4-sulfonic acid; DavePhos; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 67341-07-5
tert-butyl N-(2-hydroxy-2-phenylethyl)carbamate

: 1400670-08-7
N-{3-[6-(2-amino-1-phenylethylamino)pyridin-2-yl]imidazo[1,2-a]pyrazin-8-yl}cyclohexane-1,4-diamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / 0 - 20 °C

2: hydrazine hydrate / tetrahydrofuran; methanol / 15 h / 65 °C

3: potassium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 17 h / 135 °C / sealed tube; Inert atmosphere

4: ethanol

With potassium carbonate; hydrazine hydrate; triphenylphosphine; DavePhos; diethylazodicarboxylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;