6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethylene)-3,4-dihydro-1H-naphthalen-2-one

Base Information

• Chemical Name: 6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethylene)-3,4-dihydro-1H-naphthalen-2-one
• CAS No.: 620171-81-5
• Molecular Formula: C₃₄H₂₈N₂O₂
• Molecular Weight: 496.609
• Mol file: 620171-81-5.mol

Synonyms:6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethylene)-3,4-dihydro-1H-naphthalen-2-one

Chemical Property of 6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethylene)-3,4-dihydro-1H-naphthalen-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethylene)-3,4-dihydro-1H-naphthalen-2-one

There total 1 articles about 6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethylene)-3,4-dihydro-1H-naphthalen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

6-methoxy-2-tetralone (2472-22-2) + (1-tritylimidazol-4-yl)carboxaldehyde (33016-47-6) → 6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethylene)-3,4-dihydro-1H-naphthalen-2-one (620171-81-5)

Guidance literature:

With piperidine; In benzene; for 22h; Heating;

DOI:10.1081/SCC-120021500

Reference yield: 66.0%

6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethylene)-3,4-dihydro-1H-naphthalen-2-one (620171-81-5) → 6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethyl)-3,4-dihydro-1H-naphthalen-2-one (620171-87-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 144h;

DOI:10.1081/SCC-120021500

Reference yield:

6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethylene)-3,4-dihydro-1H-naphthalen-2-one (620171-81-5) → 6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydronaphthalen-2-ylamine

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / H₂ / 10 percent Pd/C / ethyl acetate / 144 h

2: 79 percent / NaBH₃CN; NH₄OAc / methanol / 2 h / Heating

With ammonium acetate; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In methanol; ethyl acetate;

DOI:10.1081/SCC-120021500

upstream raw materials:

6-methoxy-2-tetralone

(1-tritylimidazol-4-yl)carboxaldehyde

Downstream raw materials:

6-methoxy-1-(1-trityl-1H-imidazol-4-ylmethyl)-3,4-dihydro-1H-naphthalen-2-one