1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

Base Information

Chemical Name:1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate
CAS No.:1075237-54-5
Molecular Formula:C₃₇H₄₇N₅O₇
Molecular Weight:673.809
Hs Code.:

1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

Synonyms:1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

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Chemical Property of 1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

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Technology Process of 1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

There total 6 articles about 1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-(methyloxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one sodium salt

: 1075237-53-4
1,1-dimethylethyl [1-(2-chloro-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]-(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)carbamate

: 1075237-54-5
1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

Guidance literature:: 7-(methyloxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one sodium salt; 1,1-dimethylethyl [1-(2-chloro-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]-(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)carbamate; In N,N-dimethyl-formamide; at 20 - 60 ℃;

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Product distribution / selectivity;

Reference yield:

: 5445-44-3,32520-12-0
O-benzylserine

: 1075237-54-5
1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; potassium bromide; sodium nitrite / water / 2.58 h / 0 - 20 °C

2.1: thionyl chloride / 3 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -78 - 0 °C

4.2: 2 h / 20 °C

5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

6.1: N,N-dimethyl-formamide / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; potassium carbonate; methanesulfonyl chloride; triethylamine; potassium bromide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 42990-70-5
2-bromo-3-(phenylmethoxy)propanoic acid

: 1075237-54-5
1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-[1-(2-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 3 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -78 - 0 °C

3.2: 2 h / 20 °C

4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

5.1: N,N-dimethyl-formamide / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;