(3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one

Base Information

Chemical Name:(3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one
CAS No.:1192801-11-8
Molecular Formula:C₂₆H₂₁F₉N₄O₂
Molecular Weight:592.464
Hs Code.:

Synonyms:(3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one

There total 9 articles about (3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52771-21-8,50823-91-1
3-(trifluoromethoxy)benzaldehyde

: 1192801-11-8
(3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 0.17 h / 20 °C

1.2: 20 - 30 °C

2.1: cis,trans-2,5-dimethoxytetrahydrofuran; water; acetic acid; trifluoroacetic acid / ethanol / 18 h / 50 °C

3.1: methanol / 96 h / -7 - 20 °C

3.2: -7 - 10 °C

4.1: water; acetic acid; trifluoroacetic acid / 1 h / 20 °C

5.1: acetic acid / toluene / 18 h / 55 °C

6.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 1.08 h / 0 - 20 °C

6.2: Saturated solution

With cis,trans-2,5-dimethoxytetrahydrofuran; water; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; toluene;

Reference yield:

: 1192801-29-8
(R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-1,5-dihydro-pyrrol-2-one

: 1192801-11-8
(3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one

Guidance literature:: (R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-1,5-dihydro-pyrrol-2-one; With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; at 0 - 20 ℃; for 1.08333h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate; Saturated solution;

Reference yield:

: 1192801-22-1
2-(2-trifluoromethyl-pyrimidin-4-yl)-propan-2-ol

: 1192801-11-8
(3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 0 - 10 °C

1.2: 1 h / 90 °C

2.1: hydrogenchloride; water / 29 h / 100 °C

3.1: acetic acid / toluene / 18 h / 55 °C

4.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 1.08 h / 0 - 20 °C

4.2: Saturated solution

With hydrogenchloride; sulfuric acid; water; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; toluene;