N-(2-methoxyphenyl)-3,3-diphenylacrylamide

Base Information

• Chemical Name: N-(2-methoxyphenyl)-3,3-diphenylacrylamide
• CAS No.: 1620975-13-4
• Molecular Formula: C₂₂H₁₉NO₂
• Molecular Weight: 329.398
• Mol file: 1620975-13-4.mol

Synonyms:N-(2-methoxyphenyl)-3,3-diphenylacrylamide

Chemical Property of N-(2-methoxyphenyl)-3,3-diphenylacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-methoxyphenyl)-3,3-diphenylacrylamide

There total 2 articles about N-(2-methoxyphenyl)-3,3-diphenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-(2-methoxyphenyl)-1,1-diphenylprop-2-yn-1-ol (164401-06-3) → N-(2-methoxyphenyl)-3,3-diphenylacrylamide (1620975-13-4)

Guidance literature:

With chloro-trimethyl-silane; trimethylsilylazide; water; acetic acid; at 50 ℃; regioselective reaction; Molecular sieve;

DOI:10.1021/jo5013948

Reference yield:

1-ethynyl-2-methoxybenzene (767-91-9) → N-(2-methoxyphenyl)-3,3-diphenylacrylamide (1620975-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1 h / -78 °C

2.1: acetic acid; chloro-trimethyl-silane; trimethylsilylazide; water / 50 °C / Molecular sieve

With n-butyllithium; chloro-trimethyl-silane; trimethylsilylazide; water; acetic acid; In tetrahydrofuran;

DOI:10.1021/jo5013948

upstream raw materials:

3-(2-methoxyphenyl)-1,1-diphenylprop-2-yn-1-ol

1-ethynyl-2-methoxybenzene