(R)-3-chloro-5-methyl-3-((S)-2--nitro-1-phenylethyl)indolin-2-one

Base Information

• Chemical Name: (R)-3-chloro-5-methyl-3-((S)-2--nitro-1-phenylethyl)indolin-2-one
• CAS No.: 1398566-74-9
• Molecular Formula: C₁₇H₁₅ClN₂O₃
• Molecular Weight: 330.771
• Mol file: 1398566-74-9.mol

Synonyms:(R)-3-chloro-5-methyl-3-((S)-2--nitro-1-phenylethyl)indolin-2-one

Chemical Property of (R)-3-chloro-5-methyl-3-((S)-2--nitro-1-phenylethyl)indolin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of (R)-3-chloro-5-methyl-3-((S)-2--nitro-1-phenylethyl)indolin-2-one

There total 2 articles about (R)-3-chloro-5-methyl-3-((S)-2--nitro-1-phenylethyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ (R)-3-chloro-5-methyl-3-((S)-2--nitro-1-phenylethyl)indolin-2-one (1398566-74-9)

Guidance literature:

With C₄₉H₃₇F₆N₃O₂; In dichloromethane; at 20 ℃; for 4h; enantioselective reaction;

Reference yield:

nitrostyrene (5153-67-3) + chloro-3 methyl-5 indolinone-2 (77484-19-6) → (R)-3-chloro-5-methyl-3-((S)-2--nitro-1-phenylethyl)indolin-2-one (1398566-74-9) + C17H15ClN2O3

Guidance literature:

With C₃₂H₃₀F₆N₄O₃; In chloroform; at 4 ℃; Overall yield = 94 %; Overall yield = 31 mg;

DOI:10.1021/ol302245b DOI:10.1021/ol302245b

upstream raw materials:

nitrostyrene

chloro-3 methyl-5 indolinone-2