(3S,4S,1'S)-3-t-butoxycarbonylamino-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

Base Information

Chemical Name:(3S,4S,1'S)-3-t-butoxycarbonylamino-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one
CAS No.:859214-45-2
Molecular Formula:C₁₈H₂₆N₂O₄
Molecular Weight:334.415
Hs Code.:

Synonyms:(3S,4S,1'S)-3-t-butoxycarbonylamino-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

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Chemical Property of (3S,4S,1'S)-3-t-butoxycarbonylamino-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

Chemical Property:

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Technology Process of (3S,4S,1'S)-3-t-butoxycarbonylamino-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

There total 8 articles about (3S,4S,1'S)-3-t-butoxycarbonylamino-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859214-13-4
(3S,4S,1'S)-3-azido-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

: 859214-45-2
(3S,4S,1'S)-3-t-butoxycarbonylamino-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; ammonium chloride / methanol; H₂O / 0.25 h / 20 °C

2: 0.75 g / methanol / 12 h / 20 °C

With ammonium chloride; zinc; In methanol; water;
DOI:10.1016/j.tetasy.2005.03.003

Reference yield:

: 859214-10-1
(3R,4R,1'S)-4-benzoyloxymethyl-3-hydroxy-1-(1'-phenylethyl)pyrrolidin-2-one

: 859214-45-2
(3S,4S,1'S)-3-t-butoxycarbonylamino-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / triethylamine / CH₂Cl₂ / 2 h / 0 °C

2: 75 percent / sodium azide / dimethylsulfoxide / 4 h / 70 °C

3: 80 percent / anhydrous sodium carbonate / methanol / 5 h / 20 °C

4: zinc; ammonium chloride / methanol; H₂O / 0.25 h / 20 °C

5: 0.75 g / methanol / 12 h / 20 °C

With sodium azide; ammonium chloride; sodium carbonate; triethylamine; zinc; In methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.tetasy.2005.03.003

Reference yield:

: 859214-12-3
(3S,4S,1'S)-3-azido-4-benzoyloxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

: 859214-45-2
(3S,4S,1'S)-3-t-butoxycarbonylamino-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / anhydrous sodium carbonate / methanol / 5 h / 20 °C

2: zinc; ammonium chloride / methanol; H₂O / 0.25 h / 20 °C

3: 0.75 g / methanol / 12 h / 20 °C

With ammonium chloride; sodium carbonate; zinc; In methanol; water;
DOI:10.1016/j.tetasy.2005.03.003