2-(1-{3-[4-(4-fluoro-benzoyl)-2-propyl-phenoxy]-propyl}-1H-indol-5-yloxy)-2-methyl-propionic acid

Base Information

• Chemical Name: 2-(1-{3-[4-(4-fluoro-benzoyl)-2-propyl-phenoxy]-propyl}-1H-indol-5-yloxy)-2-methyl-propionic acid
• CAS No.: 853652-43-4
• Molecular Formula: C₃₁H₃₂FNO₅
• Molecular Weight: 517.597
• Mol file: 853652-43-4.mol

Synonyms:2-(1-{3-[4-(4-fluoro-benzoyl)-2-propyl-phenoxy]-propyl}-1H-indol-5-yloxy)-2-methyl-propionic acid

Chemical Property of 2-(1-{3-[4-(4-fluoro-benzoyl)-2-propyl-phenoxy]-propyl}-1H-indol-5-yloxy)-2-methyl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(1-{3-[4-(4-fluoro-benzoyl)-2-propyl-phenoxy]-propyl}-1H-indol-5-yloxy)-2-methyl-propionic acid

There total 2 articles about 2-(1-{3-[4-(4-fluoro-benzoyl)-2-propyl-phenoxy]-propyl}-1H-indol-5-yloxy)-2-methyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(4-fluoro-phenyl)-(4-hydroxy-3-propyl-phenyl)-methanone (874988-14-4) + ethyl 2-[1-(3-chloropropyl)-1H-indol-5-yloxy]-2-methylpropionate → 2-(1-{3-[4-(4-fluoro-benzoyl)-2-propyl-phenoxy]-propyl}-1H-indol-5-yloxy)-2-methyl-propionic acid (853652-43-4)

Guidance literature:

(4-fluoro-phenyl)-(4-hydroxy-3-propyl-phenyl)-methanone; ethyl 2-[1-(3-chloropropyl)-1H-indol-5-yloxy]-2-methylpropionate; With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 2h; Inert atmosphere;

With lithium hydroxide; In methanol; water; for 2h; Reflux; Inert atmosphere;

DOI:10.1021/jm801594x

Reference yield:

→ 2-(1-{3-[4-(4-fluoro-benzoyl)-2-propyl-phenoxy]-propyl}-1H-indol-5-yloxy)-2-methyl-propionic acid (853652-43-4)

Guidance literature:

upstream raw materials:

(4-fluoro-phenyl)-(4-hydroxy-3-propyl-phenyl)-methanone