4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

Base Information

Chemical Name:4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline
CAS No.:1207340-12-2
Molecular Formula:C₂₈H₃₂N₄O₂
Molecular Weight:456.588
Hs Code.:

Synonyms:4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

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Chemical Property of 4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

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Technology Process of 4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

There total 8 articles about 4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.5%

: 1207339-99-8
4-[(1-piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

: 4-(2-bromoethyl)phenylacetamide

: 1207340-12-2
4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

Guidance literature:: With triethylamine; sodium iodide; In butanone; for 12h; Reflux;
DOI:10.1021/jm300573d

Reference yield: 40.0%

: 1207339-99-8
4-[(1-piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

: 39232-06-9
2-bromo-1-[4-(acetylamino)phenyl]-ethane

: 1207340-12-2
4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

Guidance literature:: 4-[(1-piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline; 2-bromo-1-[4-(acetylamino)phenyl]-ethane; In butanone; for 1.5h; Reflux;

With triethylamine; In butanone; for 1.5h;

Reference yield:

: 748159-52-6
2H-pyrrolo[3,4-c]quinolin-4(5H)-one

: 1207340-12-2
4-[(1-(4-acetamidophenylethyl)piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 15 h / 90 °C

2.1: triethylamine; trichlorophosphate / 6 h / 120 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

3.2: 1 h / 146 °C

4.1: hydrogen; palladium 10% on activated carbon / acetic acid; methanol / 96 h / 20 °C / 1448.05 Torr

5.1: triethylamine; sodium iodide / butanone / 12 h / Reflux

With palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; sodium iodide; trichlorophosphate; In methanol; acetic acid; N,N-dimethyl-formamide; butanone; paraffin oil;
DOI:10.1021/jm300573d