4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal

Base Information

Chemical Name:4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal
CAS No.:170235-88-8
Molecular Formula:C₁₄H₂₀O₃
Molecular Weight:236.311
Hs Code.:

Synonyms:4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal

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Chemical Property of 4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal

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Technology Process of 4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal

There total 9 articles about 4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 170235-87-7
4-(2'-methoxymethyloxy-4'-methylphenyl)pentanol

: 170235-88-8
4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal

Guidance literature:: With Celite; pyridinium chlorochromate; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1248/cpb.43.553

Reference yield:

: 164921-74-8
methyl 4-(2'-methoxy-4'-methylphenyl)-5-hydroxy-(2E)-pentanoate

: 170235-88-8
4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / H₂, 20percent Pd(OH)2/C / ethyl acetate / 760 Torr / Ambient temperature

2: pyridine / Ambient temperature

3: 63 percent / NaBH₄ / dimethylsulfoxide / 3 h / 80 °C

4: 97 percent / pyridine / Ambient temperature

5: 97 percent / AlCl₃, EtSH / 1 h / 0 °C

6: 97 percent / NaH, 18-crown-6 / acetonitrile / 1 h / 0 °C

7: 98 percent / 2N NaOH / methanol / 0.17 h / 50 °C

8: 90 percent / PCC, celite 545 / CH₂Cl₂ / 1 h / Ambient temperature

With palladium dihydroxide; sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; 18-crown-6 ether; Celite; hydrogen; sodium hydride; pyridinium chlorochromate; ethanethiol; In pyridine; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile;
DOI:10.1248/cpb.43.553

Reference yield:

: 170235-80-0
methyl 4-(2'-methoxy-4'-methylphenyl)-5-tosyloxypentanoate

: 170235-88-8
4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal

Guidance literature:: Multi-step reaction with 6 steps

1: 63 percent / NaBH₄ / dimethylsulfoxide / 3 h / 80 °C

2: 97 percent / pyridine / Ambient temperature

3: 97 percent / AlCl₃, EtSH / 1 h / 0 °C

4: 97 percent / NaH, 18-crown-6 / acetonitrile / 1 h / 0 °C

5: 98 percent / 2N NaOH / methanol / 0.17 h / 50 °C

6: 90 percent / PCC, celite 545 / CH₂Cl₂ / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; 18-crown-6 ether; Celite; sodium hydride; pyridinium chlorochromate; ethanethiol; In pyridine; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1248/cpb.43.553