6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid

Base Information

Chemical Name:6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid
CAS No.:1584731-74-7
Molecular Formula:C₃₃H₃₆Cl₂N₂O₆S
Molecular Weight:659.631
Hs Code.:

6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid

Synonyms:6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid

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Chemical Property of 6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid

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Technology Process of 6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid

There total 6 articles about 6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1584732-24-0
methyl 6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

: 1584731-74-7
6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm401911v

Reference yield:

: 5470-70-2
Methyl 6-methylnicotinate

: 1584731-74-7
6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / 75 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.25 h / -78 °C / Inert atmosphere

2.3: 1 h / -78 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4.1: cyanomethylenetributyl-phosphorane / toluene / 12 h / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C / Inert atmosphere

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C / Inert atmosphere

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; water; 3-chloro-benzenecarboperoxoic acid; cyanomethylenetributyl-phosphorane; lithium hydroxide; lithium hexamethyldisilazane; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jm401911v

Reference yield:

: 1584732-22-8
methyl 6-(((2S,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-cyclopropyl-2-hydroxyethyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

: 1584731-74-7
6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: cyanomethylenetributyl-phosphorane / toluene / 12 h / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C / Inert atmosphere

With water; 3-chloro-benzenecarboperoxoic acid; cyanomethylenetributyl-phosphorane; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm401911v