(S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine

Base Information

Chemical Name:(S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine
CAS No.:1299465-81-8
Molecular Formula:C₂₅H₂₉N₃O₂
Molecular Weight:403.524
Hs Code.:

Synonyms:(S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine

Suppliers and Price of (S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine

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Chemical Property of (S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine

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Technology Process of (S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine

There total 6 articles about (S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1299465-81-8
(S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 75 °C

2.1: zinc; acetic acid / methanol / 20 h / 20 °C

3.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C

3.2: 60 h / 20 °C

4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; ethanol / 0.25 h / 140 °C / Microwave irradiation

5.1: dichloromethane / 4 h / 20 °C

With potassium carbonate; caesium carbonate; acetic acid; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1299466-18-4
2-(S)-({ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1299465-81-8
(S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine

Guidance literature:: 2-(S)-({ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 150-76-5
4-methoxy-phenol

: 1299465-81-8
(S)-ethyl-[2-(4-methoxy-phenoxy)-4-pyridin-3-yl-phenyl]-pyrrolidin-2-ylmethyl-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 75 °C

2.1: zinc; acetic acid / methanol / 20 h / 20 °C

3.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C

3.2: 60 h / 20 °C

4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; ethanol / 0.25 h / 140 °C / Microwave irradiation

5.1: dichloromethane / 4 h / 20 °C

With potassium carbonate; caesium carbonate; acetic acid; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;