(2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid

Base Information

Chemical Name:(2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid
CAS No.:870137-24-9
Molecular Formula:C₃₀H₄₈N₄O₁₁
Molecular Weight:640.731
Hs Code.:

(2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid

Synonyms:(2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid

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Chemical Property of (2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid

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Technology Process of (2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid

There total 5 articles about (2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912341-76-5
(2S,3R)-3-(4-Benzyloxy-3-{(R)-1-[(S)-((S)-2-benzyloxycarbonylamino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-prop-2-ynyloxy}-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid benzyl ester

: 870137-24-9
(2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid

Guidance literature:: With hydrogen; palladium; In ethanol; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2006.06.071

Reference yield:

: 870137-16-9
{[(2S,3S)-3-ethynyl-3-methyl-1-(2-nitrobenzenesulfonyl)-aziridine-2-carbonyl]amino}acetic acid tert-butyl ester

: 870137-24-9
(2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / CuOAc; DBU / toluene

2: 78 percent / PhSH; Cs₂CO₃ / dimethylformamide

3: 85 percent / EDCI*HCl; HOBt; NaHCO₃ / dimethylformamide / 20 h / 20 °C

4: H₂ / Pd / ethanol / 6 h / 20 °C

With hydrogen; copper (I) acetate; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2006.06.071

Reference yield:

: 870137-17-0
(2S,3R)-3-(4-benzyloxy-3-hydroxyphenyl)-2-(tert-butoxycarbonylmethylamino)-3-hydroxypropionic acid benzyl ester

: 870137-24-9
(2S,3R)-3-(3-{(R)-1-[(S)-((S)-2-Amino-propionylamino)-(tert-butoxycarbonylmethyl-carbamoyl)-methyl]-1-methyl-propoxy}-4-hydroxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-3-hydroxy-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / CuOAc; DBU / toluene

2: 78 percent / PhSH; Cs₂CO₃ / dimethylformamide

3: 85 percent / EDCI*HCl; HOBt; NaHCO₃ / dimethylformamide / 20 h / 20 °C

4: H₂ / Pd / ethanol / 6 h / 20 °C

With hydrogen; copper (I) acetate; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2006.06.071