3-{2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid

Base Information

Chemical Name:3-{2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid
CAS No.:638216-21-4
Molecular Formula:C₂₇H₂₈F₃NO₃
Molecular Weight:471.519
Hs Code.:

Synonyms:3-{2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid

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Chemical Property of 3-{2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid

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Technology Process of 3-{2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid

There total 10 articles about 3-{2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 638214-80-9
ethyl 3-(4-{[(1S)-1-(6-bromo-2-pyridinyl)pentyl]oxy}-2-methylphenyl)propanoate

: 638216-21-4
3-{2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid

Guidance literature:: ethyl 3-(4-{[(1S)-1-(6-bromo-2-pyridinyl)pentyl]oxy}-2-methylphenyl)propanoate; With sodium carbonate; In water; at 73 ℃; for 21h;

With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;

Reference yield:

: 638214-79-6
ethyl (2E)-3-{2-methyl-4-[(phenylmethyl)oxy]phenyl}-2-propenoate

: 638216-21-4
3-{2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 19 h / 20 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 15 h / 0 - 20 °C

3.1: sodium carbonate / water / 21 h / 73 °C

3.2: 4 h / 20 °C

With tributylphosphine; hydrogen; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; 2.1: Mitsunobu reaction;

Reference yield:

: 101093-56-5
4-benzyloxy-2-methyl-benzaldehyde

: 638216-21-4
3-{2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran

1.2: 4 h / 20 - 66 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 19 h / 20 °C

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 15 h / 0 - 20 °C

4.1: sodium carbonate / water / 21 h / 73 °C

4.2: 4 h / 20 °C

With tributylphosphine; hydrogen; sodium hydride; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; 1.1: Wittig Reaction / 3.1: Mitsunobu reaction;