6-hydroxy-3-(4-hydroxyphenyl)-1-(phenylbutyl)-2-(phenylpropyl)-2,3-dihydroindene

Base Information

Chemical Name:6-hydroxy-3-(4-hydroxyphenyl)-1-(phenylbutyl)-2-(phenylpropyl)-2,3-dihydroindene
CAS No.:132777-35-6
Molecular Formula:C₃₄H₃₆O₂
Molecular Weight:476.659
Hs Code.:

Synonyms:6-hydroxy-3-(4-hydroxyphenyl)-1-(phenylbutyl)-2-(phenylpropyl)-2,3-dihydroindene

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Chemical Property of 6-hydroxy-3-(4-hydroxyphenyl)-1-(phenylbutyl)-2-(phenylpropyl)-2,3-dihydroindene

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Technology Process of 6-hydroxy-3-(4-hydroxyphenyl)-1-(phenylbutyl)-2-(phenylpropyl)-2,3-dihydroindene

There total 4 articles about 6-hydroxy-3-(4-hydroxyphenyl)-1-(phenylbutyl)-2-(phenylpropyl)-2,3-dihydroindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-phenyl-butyl)-2-(3-phenyl-propyl)-indan

: 132777-35-6
6-hydroxy-3-(4-hydroxyphenyl)-1-(phenylbutyl)-2-(phenylpropyl)-2,3-dihydroindene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 0.25h; Yield given;
DOI:10.1021/jo00008a049

Reference yield:

: 106-41-2
4-bromo-phenol

: 132777-35-6
6-hydroxy-3-(4-hydroxyphenyl)-1-(phenylbutyl)-2-(phenylpropyl)-2,3-dihydroindene

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / imidazole / CH₂Cl₂

2: 1) t-BuLi / 1) THF, pentane, -78 deg C, 2 h, 2) THF, a) up to 0 deg C, b) 0 deg C, 30 min

3: TiCl₄ / CH₂Cl₂ / 0.75 h / 42 °C

4: (n-Bu)4NF / tetrahydrofuran / 0.25 h / 23 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; tert.-butyl lithium; titanium tetrachloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00008a049

Reference yield:

: 67963-68-2
t-butyldimethylsilyl-4-bromophenol

: 132777-35-6
6-hydroxy-3-(4-hydroxyphenyl)-1-(phenylbutyl)-2-(phenylpropyl)-2,3-dihydroindene

Guidance literature:: Multi-step reaction with 3 steps

1: 1) t-BuLi / 1) THF, pentane, -78 deg C, 2 h, 2) THF, a) up to 0 deg C, b) 0 deg C, 30 min

2: TiCl₄ / CH₂Cl₂ / 0.75 h / 42 °C

3: (n-Bu)4NF / tetrahydrofuran / 0.25 h / 23 °C

With tetrabutyl ammonium fluoride; tert.-butyl lithium; titanium tetrachloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00008a049