4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenylbutyl)morphinan-6β-ol

Base Information

Chemical Name:4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenylbutyl)morphinan-6β-ol
CAS No.:85455-23-8
Molecular Formula:C₂₉H₃₇NO₄
Molecular Weight:463.617
Hs Code.:

Synonyms:4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenylbutyl)morphinan-6β-ol

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Chemical Property of 4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenylbutyl)morphinan-6β-ol

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Technology Process of 4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenylbutyl)morphinan-6β-ol

There total 7 articles about 4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenylbutyl)morphinan-6β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: C₂₉H₃₅NO₄

: 85455-23-8
4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenylbutyl)morphinan-6β-ol

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; water; under 2585.7 Torr;
DOI:10.1021/jm00361a019

Reference yield: 89.0%

: 85479-36-3
4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenyl-1,3-butadienyl)morphinan-6β-ol

: 85455-23-8
4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenylbutyl)morphinan-6β-ol

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 6h; under 2585.7 Torr;
DOI:10.1021/jo00159a005

Reference yield:

: 1530-35-4
cinnamyltriphenylphosphonium chloride

: 85455-23-8
4,5α-epoxy-7α-(hydroxymethyl)-3-methoxy-17-methyl-7β-(4-phenylbutyl)morphinan-6β-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMSO, 25 deg C, 10 min, 2.) DMSO, room temp., 30 min, 65-70 deg C, 30 min

2: HCl / ethanol / 0.5 h / Heating

3: 89 percent / conc. HCl, H₂ / Pd/C / ethanol / 6 h / 2585.7 Torr

With hydrogenchloride; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;
DOI:10.1021/jo00159a005