(S)-2,2,2-trifluoro-1-<2-<2-(methoxymethyl)-1-pyrrolidinyl>phenyl>ethanone

Base Information

Chemical Name:(S)-2,2,2-trifluoro-1-<2-<2-(methoxymethyl)-1-pyrrolidinyl>phenyl>ethanone
CAS No.:124097-61-6
Molecular Formula:C₁₄H₁₆F₃NO₂
Molecular Weight:287.282
Hs Code.:

Synonyms:(S)-2,2,2-trifluoro-1-<2-<2-(methoxymethyl)-1-pyrrolidinyl>phenyl>ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2,2,2-trifluoro-1-<2-<2-(methoxymethyl)-1-pyrrolidinyl>phenyl>ethanone

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Technology Process of (S)-2,2,2-trifluoro-1-<2-<2-(methoxymethyl)-1-pyrrolidinyl>phenyl>ethanone

There total 3 articles about (S)-2,2,2-trifluoro-1-<2-<2-(methoxymethyl)-1-pyrrolidinyl>phenyl>ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 63126-47-6
(2S)-2-(methoxymethyl)-1-pyrrolidine

: 124004-75-7
α,α,α-trifluoro-2-fluoroacetophenone

: 124097-61-6
(S)-2,2,2-trifluoro-1-<2-<2-(methoxymethyl)-1-pyrrolidinyl>phenyl>ethanone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 65 ℃; for 72h;

Reference yield:

: 124004-74-6
α-(trifluoromethyl)-2-fluorobenzenemethanol

: 124097-61-6
(S)-2,2,2-trifluoro-1-<2-<2-(methoxymethyl)-1-pyrrolidinyl>phenyl>ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / potassium dichromate, concd. H₂SO₄ / acetic acid; H₂O / 72 h

2: 53 percent / K₂CO₃ / dimethylformamide / 72 h / 60 - 65 °C

With potassium dichromate; sulfuric acid; potassium carbonate; In water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 446-52-6
2-Fluorobenzaldehyde

: 124097-61-6
(S)-2,2,2-trifluoro-1-<2-<2-(methoxymethyl)-1-pyrrolidinyl>phenyl>ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / Zn / pyridine / 4 h / 1520 - 2660 Torr

2: 65 percent / potassium dichromate, concd. H₂SO₄ / acetic acid; H₂O / 72 h

3: 53 percent / K₂CO₃ / dimethylformamide / 72 h / 60 - 65 °C

With potassium dichromate; sulfuric acid; potassium carbonate; zinc; In pyridine; water; acetic acid; N,N-dimethyl-formamide;