Technology Process of N-benzyl-2-(5-benzyl-1,2,4-oxadiazol-3-yl)-4-methylthiazole-5-carboxamide
There total 6 articles about N-benzyl-2-(5-benzyl-1,2,4-oxadiazol-3-yl)-4-methylthiazole-5-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenylacetic acid;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
N-benzyl-2-(N'-hydroxycarbamimidoyl)-4-methylthiazole-5-carboxamide;
In
N,N-dimethyl-formamide;
for 17h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
2: isopentyl nitrite / acetonitrile / Reflux
3: hydroxylamine hydrochloride; triethylamine / ethanol / Reflux
4: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide
With
hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; isopentyl nitrite;
In
ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2013.12.036
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
2: isopentyl nitrite / acetonitrile / Reflux
3: hydroxylamine hydrochloride; triethylamine / ethanol / Reflux
4: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide
With
hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; isopentyl nitrite;
In
ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2013.12.036
