{2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester
CAS No.:862661-75-4
Molecular Formula:C₃₀H₄₂Cl₂F₃N₅O₅
Molecular Weight:680.595
Hs Code.:

{2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

There total 5 articles about {2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 851484-85-0
2,2,2-trifluoro-N-((1-(piperazin-1-yl)cyclohexyl)methyl)acetamide

: (R)-2-[3-(tert-butoxycarbonylamino)propionylamino]-3-(2,4-dichlorophenyl)propionic acid

: 862661-75-4
{2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1016/j.bmcl.2005.05.017

Reference yield:

: 139754-93-1
1-(4-benzylpiperazin-1-yl)cyclohexanecarbonitrile

: 862661-75-4
{2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / LiAlH₄ / diethyl ether / 0.5 h / 20 °C

2: 100 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 86 percent / NH₄COOH / Pd/C / methanol / 2 h / 65 °C

4: 54 percent / HBTU; EtN(iPr)2 / dimethylformamide / 8 h / 20 °C

With lithium aluminium tetrahydride; ammonium formate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.017

Reference yield:

: 511538-96-8
(1-(4-benzylpiperazin-1-yl)cyclohexyl)methanamine

: 862661-75-4
{2-[1-(2,4-dichloro-benzyl)-2-oxo-2-(4-{1-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexyl}-piperazin-1-yl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 86 percent / NH₄COOH / Pd/C / methanol / 2 h / 65 °C

3: 54 percent / HBTU; EtN(iPr)2 / dimethylformamide / 8 h / 20 °C

With ammonium formate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.017