5-bromo-N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboximidamide

Base Information

Chemical Name:5-bromo-N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboximidamide
CAS No.:1569735-74-5
Molecular Formula:C₁₈H₂₁BrN₂OS₂
Molecular Weight:425.414
Hs Code.:

Synonyms:5-bromo-N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboximidamide

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Chemical Property of 5-bromo-N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboximidamide

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Technology Process of 5-bromo-N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboximidamide

There total 5 articles about 5-bromo-N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 2160-62-5
5-bromo-2-thiophenecarbonitrile

: 1343811-07-3
3-[(cyclopentylsulfanyl)methyl]-4-methoxyaniline

: 1569735-74-5
5-bromo-N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboximidamide

Guidance literature:: 3-[(cyclopentylsulfanyl)methyl]-4-methoxyaniline; With ethylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

5-bromo-2-thiophenecarbonitrile; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml400519h

Reference yield:

: 100-17-4
para-methoxynitrobenzene

: 1569735-74-5
5-bromo-N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; sodium bromide; acetic acid / 3 h / 85 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

3.1: acetic acid; iron / 7 h / 30 - 60 °C / Inert atmosphere

4.1: ethylmagnesium bromide / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With sulfuric acid; ethylmagnesium bromide; iron; potassium carbonate; acetic acid; sodium bromide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ml400519h

Reference yield:

: 1569735-46-1
2-[(cyclopentylsulfanyl)methyl]-1-methoxy-4-nitrobenzene

: 1569735-74-5
5-bromo-N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; iron / 7 h / 30 - 60 °C / Inert atmosphere

2.1: ethylmagnesium bromide / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With ethylmagnesium bromide; iron; acetic acid; In tetrahydrofuran;
DOI:10.1021/ml400519h