3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester

Base Information

Chemical Name:3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester
CAS No.:1026962-48-0
Molecular Formula:C₂₅H₃₁N₅O₄
Molecular Weight:465.552
Hs Code.:

3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2<i>H</i>-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester

Synonyms:3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester

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Chemical Property of 3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester

Chemical Property:

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Technology Process of 3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester

There total 10 articles about 3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(4-ethoxycarbonimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester; hydrochloride

: 1026962-48-0
3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester

Guidance literature:: With ammonium carbonate; In ethanol;
DOI:10.1021/jm020485x

Reference yield:

: 210962-75-7
3-hydroxy-4-iodobenzonitrile

: 1026962-48-0
3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / K₂CO₃; KI / dimethylformamide / 60 °C

2: 94 percent / triethylamine; Pd(OAc)2 / dimethylformamide / 100 °C

3: HCl / dioxane

4: 62 percent / triethylamine; bromotripyrrolidinophosphonium hexafluorophosphate / dimethylformamide / 20 °C

5: HCl / dioxane

6: ammonium carbonate / ethanol

With ammonium carbonate; hydrogenchloride; palladium diacetate; potassium carbonate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; potassium iodide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020485x

Reference yield:

: carbonic acid 5-cyano-2-iodo-phenyl ester ethyl ester

: 1026962-48-0
3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 9.29 g / aq. NaOH / methanol; tetrahydrofuran / 4 h

2: 81 percent / K₂CO₃; KI / dimethylformamide / 60 °C

3: 94 percent / triethylamine; Pd(OAc)2 / dimethylformamide / 100 °C

4: HCl / dioxane

5: 62 percent / triethylamine; bromotripyrrolidinophosphonium hexafluorophosphate / dimethylformamide / 20 °C

6: HCl / dioxane

7: ammonium carbonate / ethanol

With ammonium carbonate; hydrogenchloride; palladium diacetate; sodium hydroxide; potassium carbonate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; potassium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020485x