Technology Process of 2-(4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-piperazin-1-yl)-nicotinonitrile
There total 6 articles about 2-(4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-piperazin-1-yl)-nicotinonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium hexamethyldisilazane / hexane; diethyl ether / 2 h / 20 °C
1.2: 0 °C / pH 12
3.1: potassium carbonate / 24 h / Reflux
4.1: lithium hydroxide / 1,4-dioxane; water / 24 h / 20 °C
5.1: thionyl chloride / 0.5 h / 60 °C
6.1: triethylamine / dichloromethane / 24 h / 20 °C
With
thionyl chloride; potassium carbonate; triethylamine; lithium hydroxide; lithium hexamethyldisilazane;
In
1,4-dioxane; diethyl ether; hexane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / 24 h / Reflux
2: lithium hydroxide / 1,4-dioxane; water / 24 h / 20 °C
3: thionyl chloride / 0.5 h / 60 °C
4: triethylamine / dichloromethane / 24 h / 20 °C
With
thionyl chloride; potassium carbonate; triethylamine; lithium hydroxide;
In
1,4-dioxane; dichloromethane; water;
