(+/-)-{4-chloro-2-[2-(2-chlorobenzylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phenoxy}acetic acid

Base Information

Chemical Name:(+/-)-{4-chloro-2-[2-(2-chlorobenzylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phenoxy}acetic acid
CAS No.:1355059-36-7
Molecular Formula:C₂₅H₂₂Cl₂N₂O₄
Molecular Weight:485.367
Hs Code.:

Synonyms:(+/-)-{4-chloro-2-[2-(2-chlorobenzylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phenoxy}acetic acid

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Chemical Property of (+/-)-{4-chloro-2-[2-(2-chlorobenzylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phenoxy}acetic acid

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Technology Process of (+/-)-{4-chloro-2-[2-(2-chlorobenzylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phenoxy}acetic acid

There total 2 articles about (+/-)-{4-chloro-2-[2-(2-chlorobenzylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phenoxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₆Cl₂N₂O₄

: 1355059-36-7
(+/-)-{4-chloro-2-[2-(2-chlorobenzylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phenoxy}acetic acid

Guidance literature:: C₂₇H₂₆Cl₂N₂O₄; With water; sodium hydroxide; In acetonitrile; at 20 ℃; for 18h;

With formic acid; In water; acetonitrile; at 20 ℃;

Reference yield:

: 1355054-43-1
(+/-)-[4-chloro-2-(1,2,3,4-tetrahydroisoquinolin-1-yl)phenoxy]acetic acid ethyl ester

: 55204-93-8
2-chlorobenzyl isocyanate

: 1355059-36-7
(+/-)-{4-chloro-2-[2-(2-chlorobenzylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phenoxy}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / acetonitrile / 18 h / 20 °C

2.1: sodium hydroxide; water / acetonitrile / 18 h / 20 °C

2.2: 20 °C

With water; triethylamine; sodium hydroxide; In acetonitrile;