Technology Process of Boc-(R)-β-homo-App-OH
There total 10 articles about Boc-(R)-β-homo-App-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
at 40 ℃;
for 0.5h;
DOI:10.1021/jm00072a024
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1 M NaOH / ethanol / 0.5 h / Ambient temperature
2: 0.17 h / 130 °C
4: 6 N aq. HCl / 4 h / Heating
5: 1N aq. NaOH / dioxane
6: isobutylchloroformiate, N-methylmorpholine / 1,2-dimethoxy-ethane / 0.08 h / -15 °C
7: diethyl ether / 0.5 h / 0 °C
8: silver benzoate, triethylamine / 0.5 h / Ambient temperature
9: 1 N NaOH / methanol / 0.5 h / 40 °C
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; silver benzoate; triethylamine; isobutyl chloroformate;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; diethyl ether; ethanol;
DOI:10.1021/jm00072a024
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1.) Na / 1.) EtOH, 0 deg C, 5 min, 2.) EtOH, reflux, 6 h
2: 1 M NaOH / ethanol / 0.5 h / Ambient temperature
3: 0.17 h / 130 °C
5: 6 N aq. HCl / 4 h / Heating
6: 1N aq. NaOH / dioxane
7: isobutylchloroformiate, N-methylmorpholine / 1,2-dimethoxy-ethane / 0.08 h / -15 °C
8: diethyl ether / 0.5 h / 0 °C
9: silver benzoate, triethylamine / 0.5 h / Ambient temperature
10: 1 N NaOH / methanol / 0.5 h / 40 °C
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; silver benzoate; sodium; triethylamine; isobutyl chloroformate;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; diethyl ether; ethanol;
DOI:10.1021/jm00072a024
