6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione

Base Information

Chemical Name:6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione
CAS No.:1394058-34-4
Molecular Formula:C₁₇H₁₀F₃N₃O₆
Molecular Weight:409.278
Hs Code.:

Synonyms:6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione

Suppliers and Price of 6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione

There total 5 articles about 6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₁₂F₃N₃O₇

: 1394058-34-4
6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione

Guidance literature:: C₁₉H₁₂F₃N₃O₇; With sodium hydroxide; at 20 ℃; for 0.5h;

With hydrogenchloride; In water; pH=1;
DOI:10.1016/j.ejmech.2012.05.036

Reference yield:

: 1394058-47-9
3-benzyloxy-7-trifluoromethyl-1H-quinazoline-2,4-dione

: 1394058-34-4
6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen bromide; acetic acid / water / 3 h / Reflux

2.1: 2 h / Reflux

3.1: nitric acid / 1.5 h / -10 - 0 °C

4.1: palladium on carbon; hydrogen / ethanol / 24 h / 2068.65 Torr

5.1: sodium acetate; acetic acid / 36 h / 60 °C

5.2: pH 4

6.1: sodium hydroxide / 0.5 h / 20 °C

6.2: pH 1

With palladium on carbon; hydrogen bromide; hydrogen; nitric acid; sodium acetate; acetic acid; sodium hydroxide; In ethanol; water;
DOI:10.1016/j.ejmech.2012.05.036

Reference yield:

: 1394058-49-1
3-acetoxy-7-trifluoromethyl-1H-quinazoline-2,4-dione

: 1394058-34-4
6-(2-carboxybenzoylamino)-7-trifluoromethyl-3-hydroxy-1H-quinazoline-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: nitric acid / 1.5 h / -10 - 0 °C

2.1: palladium on carbon; hydrogen / ethanol / 24 h / 2068.65 Torr

3.1: sodium acetate; acetic acid / 36 h / 60 °C

3.2: pH 4

4.1: sodium hydroxide / 0.5 h / 20 °C

4.2: pH 1

With palladium on carbon; hydrogen; nitric acid; sodium acetate; acetic acid; sodium hydroxide; In ethanol;
DOI:10.1016/j.ejmech.2012.05.036