(2S,3R,4R,5R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

Base Information

Chemical Name:(2S,3R,4R,5R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol
CAS No.:140925-52-6
Molecular Formula:C₂₆H₄₀O₄Si
Molecular Weight:444.687
Hs Code.:

Synonyms:(2S,3R,4R,5R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

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Chemical Property of (2S,3R,4R,5R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

Chemical Property:

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Technology Process of (2S,3R,4R,5R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

There total 10 articles about (2S,3R,4R,5R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3R,4R,5R,6S)-1-Benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-3,5-diol

: 140925-52-6
(2S,3R,4R,5R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 12h; Yield given;
DOI:10.1016/S0040-4039(00)77718-5

Reference yield:

: 116661-40-6
(2S,4S,5S)-1-(benzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one

: 140925-52-6
(2S,3R,4R,5R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) n-Bu₂BOMe, LiBH₄, 2) H₂O₂ / 1) THF, MeOH, -78 deg C, 1 h, 2) pH₇ buffer, 20 deg C, 1 h

2: 1) BH₃*THF, 2) NaOOH / 1) THF, 20 deg C, 1 h

3: Et₃N, DMAP / CH₂Cl₂ / 12 h / 20 °C

4: H₂ / 10percent Pd/C / ethanol / 12 h / 20 °C

With dmap; lithium borohydride; borane-THF; sodium hydroperoxide; dibutylborinic acid methyl ester; hydrogen; dihydrogen peroxide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)77718-5

Reference yield:

: 140925-41-3
(2S,3R,4S,5R,6S)-7-Benzyloxy-2,4,6-trimethyl-heptane-1,3,5-triol

: 140925-52-6
(2S,3R,4R,5R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,4,6-trimethyl-heptane-1,3,5-triol

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, DMAP / CH₂Cl₂ / 12 h / 20 °C

2: H₂ / 10percent Pd/C / ethanol / 12 h / 20 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)77718-5