3'-O-(P-(2-cyanoethoxy)-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine

Base Information

• Chemical Name: 3'-O-(P-(2-cyanoethoxy)-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine
• CAS No.: 1278593-90-0
• Molecular Formula: C₄₇H₅₄N₉O₁₀P
• Molecular Weight: 935.974
• Mol file: 1278593-90-0.mol

Synonyms:3'-O-(P-(2-cyanoethoxy)-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine

Chemical Property of 3'-O-(P-(2-cyanoethoxy)-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-(P-(2-cyanoethoxy)-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine

There total 2 articles about 3'-O-(P-(2-cyanoethoxy)-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine (1278593-89-7) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 3'-O-(P-(2-cyanoethoxy)-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine (1278593-90-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c0ob00438c

Reference yield:

2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine (177980-10-8) + N-1-propargylthymine (198827-85-9) → 3'-O-(P-(2-cyanoethoxy)-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine (1278593-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / pyridine; water; tert-butyl alcohol / 19 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In pyridine; water; 1,2-dichloro-ethane; tert-butyl alcohol;

DOI:10.1039/c0ob00438c

upstream raw materials:

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(thymin-1-ylmethyl)-1,2,3-triazole-1-yl)uridine

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

N-1-propargylthymine