Technology Process of 5-(7-(5-(4-fluorobenzyl)-1,2,4-oxadiazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid
There total 8 articles about 5-(7-(5-(4-fluorobenzyl)-1,2,4-oxadiazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 5-(7-(5-(4-fluorobenzyl)-1,2,4-oxadiazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate;
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
water;
pH=2 - 3;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / dichloromethane / 0 - 40 °C
2.1: acetic anhydride / 5 h / 150 °C
3.1: acetic acid / 1 h / 100 °C
4.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.75 h / 100 °C / microwave irradiation
5.1: hydroxylamine hydrochloride; triethylamine / methanol / microwave irradiation; Reflux
6.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C
6.2: 16 h / 80 °C
7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
7.2: pH 2 - 3
With
hydroxylamine hydrochloride; water; acetic anhydride; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; lithium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / dichloromethane / 0 - 40 °C
2.1: acetic anhydride / 5 h / 150 °C
3.1: acetic acid / 1 h / 100 °C
4.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.75 h / 100 °C / microwave irradiation
5.1: hydroxylamine hydrochloride; triethylamine / methanol / microwave irradiation; Reflux
6.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C
6.2: 16 h / 80 °C
7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
7.2: pH 2 - 3
With
hydroxylamine hydrochloride; water; acetic anhydride; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; lithium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
