2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide

Base Information

Chemical Name:2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide
CAS No.:1266120-60-8
Molecular Formula:C₁₆H₁₄BClFNO₃
Molecular Weight:333.554
Hs Code.:

Synonyms:2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide

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Chemical Property of 2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide

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Technology Process of 2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide

There total 7 articles about 2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1266320-01-7
6-amino-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

: 21900-54-9
2-chloro-4-fluorobenzoyl chloride

: 1266120-60-8
2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide

Guidance literature:: With triethylamine; at 20 ℃;

Reference yield:

: 244205-40-1
(2-bromophenyl)boronic acid

: 1266120-60-8
2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 2 h / 50 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

2.3: 0.5 h / 20 °C

3.1: trifluoroacetic acid; trifluoroacetic anhydride / 5 °C / Cooling with ice

3.2: 0 - 5 °C

4.1: hydrogen / 5% Pd(II)/C(eggshell) / tetrahydrofuran / 16 h

5.1: triethylamine / 20 °C

With n-butyllithium; hydrogen; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; 5% Pd(II)/C(eggshell); In tetrahydrofuran; hexane; toluene;

Reference yield:

: 610-94-6
2-bromobenzoic acid methyl ester

: 1266120-60-8
2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; 2-methyltetrahydrofuran / 20 °C / Cooling with ice

1.2: 0 °C / pH 6

2.1: methylmagnesium bromide / tetrahydrofuran / 0 °C / Cooling with ice

2.2: -40 °C / Cooling with acetone-dry ice

2.3: 20 °C

3.1: trifluoroacetic acid; trifluoroacetic anhydride / 5 °C / Cooling with ice

3.2: 0 - 5 °C

4.1: hydrogen / 5% Pd(II)/C(eggshell) / tetrahydrofuran / 16 h

5.1: triethylamine / 20 °C

With methylmagnesium bromide; hydrogen; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 2-methyltetrahydrofuran;