1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester

Base Information

Chemical Name:1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester
CAS No.:173197-31-4
Molecular Formula:C₃₀H₃₂O₁₃
Molecular Weight:600.576
Hs Code.:

Synonyms:1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester

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Chemical Property of 1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester

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Technology Process of 1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester

There total 5 articles about 1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 116515-66-3
α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol

: 158504-57-5
bis[(S)-1-methoxycarbonylethyl] but-2-ynedioate

: 173197-31-4
1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester

Guidance literature:: With acetic acid; In dichloromethane; at 140 ℃; for 1h;
DOI:10.1021/jo952048e

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 173197-31-4
1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pTsOH*5H₂O / benzene / 3 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) -78 deg C, 30 min, rt, 2.5 h

3: 85 percent / AcOH / CH₂Cl₂ / 1 h / 140 °C

With n-butyllithium; toluene-4-sulfonic acid; acetic acid; In dichloromethane; benzene;
DOI:10.1021/jo952048e

Reference yield:

: 103477-58-3
2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane

: 173197-31-4
1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid bis-((S)-1-methoxycarbonyl-ethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) -78 deg C, 30 min, rt, 2.5 h

2: 85 percent / AcOH / CH₂Cl₂ / 1 h / 140 °C

With n-butyllithium; acetic acid; In dichloromethane;
DOI:10.1021/jo952048e